Search on: PROTEIN AGGREGATION, PATHOLOGICAL 
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Descriptor English:   Protein Aggregation, Pathological 
Descriptor Spanish:   Agregación Patológica de Proteínas 
Descriptor Portuguese:   Agregação Patológica de Proteínas 
Synonyms English:   Aggregation, Pathological Protein
Pathological Protein Aggregation  
Tree Number:   C23.550.770
G02.111.675
Definition English:   A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION, POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS. 
See Related English:   Protein Aggregates
 
History Note English:   2015 
Allowable Qualifiers English:  
BL blood CF cerebrospinal fluid
CI chemically induced CL classification
CO complications CN congenital
DI diagnosis DG diagnostic imaging
DH diet therapy DT drug therapy
EC economics EM embryology
EN enzymology EP epidemiology
EH ethnology ET etiology
GE genetics HI history
IM immunology ME metabolism
MI microbiology MO mortality
NU nursing PS parasitology
PA pathology PP physiopathology
PC prevention & control PX psychology
RT radiotherapy RH rehabilitation
SU surgery TH therapy
UR urine VE veterinary
VI virology  
Record Number:   55596 
Unique Identifier:   D066263 

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